Search results for " Depressive-like behaviou"

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Nuovi derivati della Dopamina nell’Addiction da sostanze d’abuso: studi preclinici su modelli sperimentali murini

Dopamine derivatives CNS delivery Acetaldehyde Animal Behaviour Analysis Addiction Dopaminergic Neurotransmission Alcoholism Depressive-like behaviour cognitive flexibility in silico modelling molecular docking.Settore CHIM/09 - Farmaceutico Tecnologico ApplicativoSettore BIO/14 - Farmacologia
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The role of pregnenolone sulphate in spatial orientation-acquisition and retention: An interplay between cognitive potentiation and mood regulation

2013

Abstract Neurosteroids can alter neuronal excitability interacting with specific neurotransmitter receptors, thus affecting several functions such as cognition and emotionality. In this study, we investigated, in adult male rats, the effects of the acute administration of pregnenolone-sulfate (PREGS) (10 mg/Kg, s. c.) on cognitive processes using the Can test, a non aversive spatial/visual task which allows the assessment of spatial information-acquisition during the baseline training, and of memory retention in the longitudinal study. Furthermore, on the basis of PREGS pharmacological profile, the modulation of depressive-like behaviour was also evaluated in the forced swim test (FST). Our…

MalePregnenolone-sulphate Spatial orientation-acquisition Spatial orientation-retention Cognitive map Depressive-like behaviouNeuroactive steroidMotor ActivityDevelopmental psychologyBehavioral NeuroscienceCognitionMemoryEmotionalityOrientationmedicineAnimalsLearningLongitudinal StudiesRats WistarNootropic AgentsSwimmingDepressionWorking memoryCognitionLong-term potentiationGeneral Medicinemedicine.diseaseRatsAffectMoodMood disordersData Interpretation StatisticalPregnenoloneSpace PerceptionSettore BIO/14 - FarmacologiaAnimal Science and ZoologyPsychologyNeuroscienceBehavioural despair test
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